Drug synthesis – an example

Oxazolomycin A core. Looks pretty bad!

Drugs are exceedingly complicated molecules. The process of getting to know what a drug should look like is, in the words of Edward Holson, Director of Medicinal Chemistry at the Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, “like a chess game.”

Nature’s mirrors

Once, I heard that the more symmetrical a face between the left and right sides, the more attractive it is. This occurred to me again when I was doing my eyebrows last night and accidentally trimmed a little too much off my left eyebrow. But while our reflections in the mirror act exactly as we do, the same certainly does not hold true for molecules.

Ashtanga yoga moon day

Crescent moon. Image obtained from Wikimedia.org

Today was a ‘moon day’ for ashtanga yoga practitioners. It reminds me of the time when I was in India practicing at 5am six days a week, unless, of course, there’s a moon day.

Introducing.. Carbon Dioxide Fertilization

Bison in Yellowstone National Park. Copyright XiaoZhi Lim 2007

I have just been introduced to a whole new concept, coined the carbon dioxide fertilization effect, when I came across an article published last week in Nature Climate Change. Can carbon dioxide actually act as a fertilizer, helping plants to grow bigger and faster with higher levels in the atmosphere?

Fish, mercury and ADHD

Got out of bed at 4am for super, super fresh sashimi. Best meal in my life - Tsujiki Fish Market, Tokyo. Copyright XiaoZhi Lim 2009.

I was browsing through EurekAlert the other day for new studies to blog about and came across this title: Low-level mercury exposure in pregnant women connected to risk in Attention Deficit Hyperactivity Disorder (ADHD). Now, I normally wouldn’t follow through on such an article, as I am: a. not pregnant, b. everyone knows mercury is toxic, so it shouldn’t be surprising that it causes problems. But the word ‘fish’ in the press release got my attention because I love eating fish and yes, I like to know what’s going on with my food, so I clicked on it and read the paper.

Print the Organ that You Need

Imagine printing a picture on a piece of paper, and printing over it repeatedly such that the picture ‘grows’ out of the paper and into a three-dimensional structure. Researchers from University of California, San Diego and collaborators from Zhejiang University did that, but with biocompatible polymers instead of regular ink to form complex three-dimensional scaffolds. The researchers can then inject living cells into these scaffolds to create artificial organs.

Tofu, contact lens and cartilage

Image obtained from Wikimedia.org

For many people with severely torn ligaments or knee replacements, the ability to run and jump as though they have never been injured before remains a dream. Tissue engineering might lead to the day when damaged cartilage can simply be replaced with synthetic materials that resemble human tissue, giving injured joints new life. In an article published last week in Nature, that day comes closer when a team of eight scientists reported the synthesis of a novel hydrogel that is extraordinarily strong, stretchable and capable of self-healing.